Background: 308 nm excimer laser phototherapy is efficacious in the treatment of localized psoriasis. Over 15 weeks the difference in mean modified PASI scores between the excimer laser-treated site and the control site was statistically significant (P<0.001) with the excimer treatment group showing substantial improvement and clearance.37, In another study by Morison et al 35 patients with scalp psoriasis who had failed prior intensive topical therapy were treated with the excimer laser. If clearance in the fastest possible time is the goal, the MBD protocol would be the best option. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. However, the laser has not shown improvement in alopecia universalis, alopecia totalis, or patches on the extremities.32, First described in 1997 by Bonis et al, the 308 nm excimer laser has become a major tool in the armamentarium of the dermatologist in treating various types of cutaneous diseases. Several topicals have been studied including dithranol ointment, flumetasone/salicylic acid ointment, calcipotriol ointment, clobetasol spray, and calcitriol ointment.27–30 In one study by Rogalski et al, addition of dithranol ointment to the excimer laser protocol resulted in a reduced Psoriasis Area and Severity Index (PASI) score.27 Furthermore, use of flumetasone/salicylic acid ointment resulted in a lower cumulative UVB dose, as well as plaque improvement. Morison WL, Atkinson D, Werthman L. Effective treatment of scalp psoriasis using the excimer (308 nm) laser. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Initially used in the treatment of refractory moderate plaque psoriasis, the 308 nm excimer laser uses UVB light to induce apoptosis, break DNA strands and, ultimately, decrease T-lymphocyte proliferation. Epub 2020 Feb 14. This FDA-approved method uses a … Single blinded left-to-right comparison study of excimer laser versus pulsed dye laser for the treatment of nail psoriasis. Skin Therapy Lett. Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. Excimer lasers aim a high intensity ultraviolet B (UVB) light dose of a very specific wavelength -- 308 nanometers -- directly at the psoriasis plaques. After 5weeks, 1session per week, the condition significantly improved (Fig. Excimer laser treatment is highly effective in psoriasis, another T cell–mediated disorder that shares many immunologic features with AA. Dove Medical Press is a member of the OAI. The stigmata of atopic dermatitis, including: erythema, infiltration, lichenification, excoriations and pruritus can severely impact a patient’s quality of life. This again supports the viability of using the excimer laser in combination treatment with other treatment modalities for psoriasis.42, Furthermore, Dong et al demonstrated that combination therapy with the excimer laser and flumetasone ointment achieved greater improvements in PASI scoring than excimer laser monotherapy, with combination treatment patients achieving an average PASI improvement of 82.51 and excimer monotherapy patients achieving an average PASI improvement of 72.01. Psoriasis vulgaris compromises more than 80% of cases, usually present with raised, well-demarcated, erythematous oval plaques with adherent silvery scale. Dong J, He Y, Zhang X, Wang Y, Tian Y, Wang J. Treatment of scalp psoriasis can be performed by moving the patients’ hair to expose the psoriatic plaques and then treating. 2014;5:8–12. The 308 nm excimer laser is an effective therapy for psoriasis regardless of the method used to determine initial dosage, dose fluency, or number of treatments. The right-hand nails were treated with excimer laser twice weekly for 12 weeks and the left-hand nails were treated with PDL once every 4 weeks for a total of 12 weeks. The UVB emitted from the laser helps regulate the p53 tumor suppressor pathway inducing cell cycle arrest and deterring inflammatory processes.15 As a result, repigmentation of the treated areas is thought to occur due to elevated levels of peptide ET-1, as well as melanocyte re-migration and proliferation.1 With this knowledge, the utilization of the excimer laser has been expanded to include a host of various cutaneous diseases. USA.gov. Physica-Verlag, Springer: Heidelberg. After 5 weeks of therapy (receiving a total of nine excimer laser treatments and clobetasol spray twice daily) the patients’ hairline psoriasis was completely cleared. psoriasis plaques and plays an important role in … As its usage as a targeted monotherapy increases, future trials should consider evaluating and modifying these parameters to determine the most optimal management of localized psoriasis. Pediatr Dermatol. Number 3099067. It became clear in assessing these various protocols that the most efficacious protocol was the MBD protocol, in which patients were treated all the way up to a sub-blistering starting dose, and followed accordingly with dose modulation as needed. You can learn about our use of cookies by reading our Privacy Policy. Taylor CR, Racette AL. 2012;28:293–298. Because XTRAC delivers a highly targeted, therapeutic beam of UVB light only to areas of the skin affected by psoriasis, healthy skin surrounding the lesions stays that way. •  Associations & Partners   Each of these protocols make use of different features of the patients’ psoriasis to help determine the optimal dosimetry when utilizing the excimer laser. Mehraban S, Feily A. Excimer laser for psoriasis treatment: A case report and short review. Photodermatol Photoimmunol Photomed. The excimer laser was invented in 1970 by Nikolai Basov et al by using a xenon dimer (Xe2). The above percentage of manuscripts have been rejected in the last 12 months. The study was conducted by Dr. Albert Marchetti, a leading health economic researcher and an adjunct professor at Rutgers New Jersey Medical School, and compared common interventions to treat plaque psoriasis. Javascript is currently disabled in your browser. The authors thank Kristina Lee (University of California–San Francisco, Department of Dermatology, Psoriasis and Skin Treatment Center, San Francisco, CA, USA) and Rasnik Singh (University of California–Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA). Vitiligo will be useful the most to treat mi ld, moderate and eve N severe but.! T lymphocytes, dendritic cells, keratinocytes, neutrophils, and 49 % of the 30 patients enrolled %. Then treated for 12 days following the initial treatment dose using either minimal! A sub-blistering does of 800 mJ, Bodendorf MO, Kauer F, Nguyen TV Koo! Debbaneh M, Bodendorf MO, Kauer F, Nguyen TV, T. Bj, Lozano AM, Murphy F, Gottlieb a ; 21 ( 1 ):54-60. doi 10.3892/etm.2020.8529. And several other advanced features are temporarily unavailable: //www-03.ibm.com/press/us/en/pressrelease/39829, Creative Attribution... Review of protocols for 308 nm, psoriasis, a vast number of other cutaneous diseases can be! 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